CpGPAP: CpG island predictor analysis platform
نویسندگان
چکیده
منابع مشابه
Bidding the CpG island goodbye
Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
متن کاملPredicting aberrant CpG island methylation.
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of methylated genes. However, little is known about why certain ge...
متن کاملGATA5 CpG island hypermethylation is an independent predictor for poor clinical outcome in renal cell carcinoma
Transcriptional inactivation and CpG island (CGI) methylation of GATA transcription factor family members GATA3 and GATA5 have been reported for a few types of human cancer. Whether high-density CGI methylation of GATA3 or GATA5 is associated with the clinical course of patients with renal cell cancer (RCC) has not been clarified. Quantitative methylation-specific PCR assays were carried out to...
متن کاملCpG Island Mapping by Epigenome Prediction
CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by simple DNA sequence criteria, which allowed for genome-wide annotation of CpG islands in the absence of large-scale epigenetic datasets. Although widely used, the current CpG island criteria incur sign...
متن کاملMETHYLATION OF ThE ANDROGEN RECEPTOR CPG ISLAND
Survivinis a memberofthe inhibitor ofapoptosis protein (IAP)family. WeInvestigated the antiapoptotic mechanism ofSurvivin, as well as its expressionIn 60 human tumor cell lines used for the National Cancer lontitute's anticancer drag screening program, In cotransfection experhnents, cell deathInduced by Bax or Faa (CD 95) was partially inhibited (mean ±SD,65%±8%)bySurv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Genetics
سال: 2012
ISSN: 1471-2156
DOI: 10.1186/1471-2156-13-13